Beware of Costume Contacts

beware-of-costume-contacts.jpgCostume Contact Lenses such as cat eyes or zombie may make your Halloween costume a bit more frightful although wearing those lenses without a prescription can be more terrifying, as it could result in vision loss or even blindness.

You can buy contact lenses, including decorative contact lenses, from your eye doctor or on the Internet.  It’s very important that you only buy contact lenses from a company that sells FDA-cleared or approved contact lenses and requires you to provide a prescription.  Even if you don’t wear corrective lenses you still need to get fitted properly.

Remember — Buying contact lenses without a prescription is dangerous!

Right now there are a lot of products that you can buy without a prescription but they may not be safe or legal.

You should NEVER buy lenses from:

  • street vendors
  • salons or beauty supply stores
  • boutiques
  • flea markets
  • novelty stores
  • Halloween stores
  • convenience stores
  • beach shops
  • internet sites that do not require a prescription

Know the Risks –

Wearing costume contact lenses can be risky, just like the contact lenses that correct your vision. Wearing any kind of contact lenses, including costume lenses, can cause serious damage to your eyes if the lenses are obtained without a prescription or not used correctly.

These risks include:

  • A cut or scratch on the top layer of your eyeball (Corneal Abrasion)
  • Allergic reactions like itchy, watery red eyes
  • Decreased vision
  • Infection
  • Blindness

Signs of possible eye infection:

  • Redness
  • Pain in the eye(s) that doesn’t go away after a short period of time
  • Decreased vision

If you have any of these signs, you need to see a licensed eye doctor (optometrist or ophthalmologist) right away!  An eye infection could become serious and cause you to become blind if it is not treated.

This Halloween season DEF wants to remind you of the importance of eye safety and to make sure to take the proper steps in ensuring the proper contact lenses.

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https://www.lvcenter4sight.com/beware-of-costume-contacts/

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The Human Drama

All of us are players in the human drama, and there are moments when we get to observe it up close and very personal. I was in Chicago, preparing to speak in an ophthalmology practice. As I often do, I arrived early to sit in the waiting area and work to get a feel for the energy and style of the practice. I didn’t mean to overhear their conversation, but as I listened, I was deeply touched by their love and in that moment, their fear.

I learned that Charlie was 88 and Rose was 86. I am sure they were holding hands as Rose was saying “Oh, Charlie, I am so sorry about the falls I have had. I just can’t see the step from the kitchen into the family room.”

Charlie tried to comfort her. “It’s alright Dear, the Doctor will give us the answers, and I am sure you’ll be better.”

I didn’t speak to Charlie over the next 40 minutes believing that I would be intruding but sure that he was living every second of the exam going on just a few steps away.

When Rose exited the Doctor’s office, she was supported by the Doctor and a Tech who must have been holding her up because she collapsed into her husband’s arms.

“I’m sorry,” she kept saying.  “I am sorry Charlie. It’s Macular Degeneration.  And, the Doctor says there’s very little he can do for me.”

the-human-drama.jpgI could hear Charlie rubbing his wife’s shoulders and telling her that everything would be alright. But, Rose kept saying “I know we’ll have to sell the house and move into something smaller, and I am going to be blind Charlie. Blind.”

Moments like this are happening across the country in ophthalmology and optometry practices every day. 30% of adults, age 60 and older, suffer from this horrible disease, and only through research will answers be found.

The Discovery Eye Foundation is committed to finding those difficult answers and making it possible for people like Rose to see the faces of loved ones for many years to come.

the-human-drama-1.jpgTom Sullivan
DEF’s Ambassador of Vision
sullivanvision.com

https://www.lvcenter4sight.com/the-human-drama/

Apellis Launches Phase 3 Clinical Trial Program for Advanced Dry AMD Treatment

The biopharmaceutical company Apellis has treated the first patient in its Phase 3 clinical trial program for APL-2, a compound designed to slow the progression of advanced dry age-related macular degeneration (AMD) also known as geographic atrophy (GA).

The Phase 3 program consists of two clinical trials: DERBY and OAKS. Each will enroll 600 patients. Trial participants will receive intravitreal injections of APL-2, or a sham procedure (placebo), monthly or every other month. The injections are made into the vitreous, the soft gel in the middle of the eye.

In the Phase 2 clinical trial, monthly injections of APL-2 slowed the growth of GA lesions by 29 percent. GA lesions are the regions in the retina where loss of cells occurs. Cell loss correlates with vision loss.

APL-2 is designed to slow the progression of GA by inhibiting C3, a protein in the complement system. While complement is part of the human immune system that wards off harmful bacteria and viruses, it can cause damage if not controlled properly. Researchers have strong evidence that an overactive complement system is involved in the death of retinal cells in AMD.

According to Apellis, 1 million people in the United States have GA, a progressive condition which causes central vision loss. There are currently no FDA-approved treatments for GA.

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Vision Improvements Reported in ProQR’s Clinical Trial for LCA10 Treatment

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ProQR, a biotech company in the Netherlands, has reported vision improvements for patients in a Phase 1/2 clinical trial for QR-110, a therapy for people with Leber congenital amaurosis 10 (LCA10), which is caused by the p.Cys998X mutation in the CEP290 gene. The mutation is estimated to affect about 2,000 people in the Western world.

The company reported that 60 percent of subjects in the trial demonstrated improvements in visual acuity and their ability to navigate a mobility course. The treatment was also safe for patients.

As a result of the encouraging interim results, ProQR has concluded the Phase 1/2 trial and plans to move the treatment into a Phase 2/3 clinical trial. Ten people were treated in the Phase 1/2 study.

Results from the interim analysis were presented on September 5, 2018, at the Retinal Degeneration 2018 meeting in Killarney, Ireland, by principal investigator Artur Cideciyan, PhD, research professor of ophthalmology at the Scheie Eye Institute, University of Pennsylvania.

The Foundation Fighting Blindness has entered into a partnership with ProQR to develop a retinal therapy for people with Usher syndrome type 2A (USH2A) caused by mutations in exon 13 of the USH2A gene. FFB will be investing up to $7.5 million in milestone-based funding to advance the treatment, known as QR-421a.

“The results from ProQR’s trial are great news for people with LCA10. Furthermore, the safety and vision improvements observed in the study provide strong evidence that antisense oligonucleotides, ProQR’s treatment approach, are an effective way to save and restore the vision of people with retinal diseases,” says Ben Yerxa, PhD, chief executive officer at FFB. “ProQR’s results for QR-110 are groundbreaking, because it is the first time this treatment approach has improved vision in humans with retinal disease.”

ProQR’s LCA10 therapy is an antisense oligonucleotide (AON), which works like “genetic tape” to repair the mutation. Unlike gene replacement therapies in which copies of whole genes are delivered to replace defective copies, AONs correct the mutation in the patient’s messenger RNA, which conveys genetic information for protein production. AONs can be advantageous when large retinal-disease genes — such as CEP290 or USH2A — exceed the capacity of viral gene-replacement delivery systems.

Patients in the LCA10 Phase 1/2 trial are receiving four intravitreal injections of QR-110 into one eye—one injection every three months. The trial is being conducted at three centers: the University of Iowa, Iowa City, Iowa; the Scheie Eye Institute at the University of Pennsylvania, Philadelphia; and the Ghent University Hospital, Ghent, Belgium.

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FFB Congratulates RPE65 Gene Therapy Researchers for Champalimaud Award

More than two decades ago, the Foundation Fighting Blindness (FFB) began funding RPE65 gene therapy research that led in late 2017 to LUXTURNA™, the first FDA-approved gene therapy for the eye or an inherited condition. Ultimately, the Foundation provided more than $10 million in funding for the groundbreaking effort.

On September 4, 2018, seven researchers, including six previously funded by the Foundation, were recognized with the prestigious 2018 Antonio Champalimaud Vision Award for their contributions to the advancement of blindness-reversing RPE65 gene therapies. The investigators received a prize of one million euros ($1.15 million).

Mutations in the RPE65 gene cause Leber congenital amaurosis and retinitis pigmentosa, both of which lead to devastating, progressive vision loss.

The awardees included:

  • Jean Bennett, MD, PhD, Scheie Eye Institute, University of Pennsylvania School of Medicine, and Albert M. Maguire, MD, Children’s Hospital of Philadelphia. Their RPE65 gene-therapy research and human studies led to the development of LUXTURNA™.
  • Robin Ali, PhD, and James Bainbridge,MD, PhD, Institute of Ophthalmology of the University College London and Moorfields Eye Hospital, who led an RPE65 gene therapy clinical trial.
  • Samuel G. Jacobson, MD, PhD, Scheie Eye Institute, University of Pennsylvania School of Medicine, and William W. Hauswirth, PhD, University of Florida College of Medicine, who conducted extensive RPE65 gene therapy research and development, and ultimately, a clinical study.
  • Michael Redmond, PhD, National Eye Institute, who identified the role of the RPE65 gene in vitamin A processing in the retina.

“We congratulate the Champalimaud Award recipients for their groundbreaking advancements in gene therapy research, and the impact their breakthroughs in retinal-disease gene-therapy development,” says Stephen Rose, PhD, FFB’s chief scientific officer. “Thanks in part to their success, people with LCA or RP caused by biallelic mutations in the RPE65 gene could be eligible to receive this FDA-approved vision-restoring treatment. In addition, this advancement has led the way for development of many more retinal gene therapies. There are now approximately 20 clinical trials underway for retinal gene therapies including those for Stargardt disease, Usher syndrome, and retinitis pigmentosa.”

The António Champalimaud Vision Award is given alternately between contributions to overall vision research (even numbered years) and contributions to the alleviation of visual problems, primarily in developing countries (odd numbered years).

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September is Healthy Aging Month

september-is-healthy-aging-month.jpgToday, people are living longer than ever before so it’s important to be proactive and take responsibility for your health as you age.

Like any other organ in your body, your eyes do not stay the same as you get older. Vision changes are normal with age but vision loss and blindness is not.  Older adults are at higher risk for certain eye diseases and conditions, including age-related macular degeneration, cataract, diabetic retinopathy, glaucoma, dry eye, and low vision.  To continue to enjoy healthy vision as you advance in years, it’s important to have a comprehensive dilated eye examination with an ophthalmologist on a regular basis.

Here are some other tips to maintain healthy vision now and as you age:

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  • Eat a healthy, balanced diet. Fruits and vegetables can help keep your eyes healthy. Visit our website for healthy eye recipes, click here Eye Cook.
  • september-is-healthy-aging-month-2.jpgMaintain a healthy weight. Being overweight increases your risk for diabetes. By exercising regularly, you can help prevent vision loss.
  • september-is-healthy-aging-month-3.jpgDon’t smoke. Smoking increases your risk for age-related macular degeneration, cataract, and other eye diseases and conditions that can damage the optic nerve.
  • september-is-healthy-aging-month-4.jpgWear protective eyewear when outdoors. Protecting your eyes from the sun’s ultraviolet rays when you are outdoors is vital for your eye health.  Wearing sunglasses that block 99 to 100 percent of both UV-A and UV-B radiation.
  • september-is-healthy-aging-month-5.jpgKnow your family history.  Talk to your family members about their eye health history. It’s important to know if anyone has been diagnosed with a disease or condition since many are hereditary. This will help determine if you are at higher risk for developing an eye disease or condition.
  • september-is-healthy-aging-month-6.jpgConsider a multivitamin. Vitamins A (beta-carotene), C, E and the mineral zinc have been shown to promote eye health.  A vitamin called Preservision has been known to help patients with moderate to severe age-related macular degeneration.
  • september-is-healthy-aging-month-7.jpgGive your eyes a rest.  If you spend a lot of time at the computer or focusing at any one distance, you sometimes forget to blink, resulting in dryness and eye fatigue. Every 20 minutes, look away about 20 feet in front of you for 20 seconds. This can help reduce eyestrain.

You can’t stop time, but you can take care of your eyes so that they remain healthy as you age. Having a healthy vision can be possible at any age!

https://www.lvcenter4sight.com/september-is-healthy-aging-month/

Ophthotech is Advancing an Impressive Portfolio of Cutting-Edge Therapies for Retinal Diseases

Audio version:

Ophthotech is a biopharmaceutical company committed to developing therapeutics and gene therapy solutions to treat retinal diseases. The company is aggressively pursuing therapies for orphan conditions like retinitis pigmentosa (RP), Stargardt disease, and Leber congenital amaurosis (LCA), as well as common indications such as wet and dry age-related macular degeneration (AMD).

Most impressive, the company is taking on a multi-track strategy that includes retinal gene-therapy development, including delivery of over-sized genes and design of a two-step process of gene knockdown and replacement for autosomal dominant conditions.

While these are the scientific challenges that keep most retinal researchers awake at night, Ophthotech thrives on them and sees them as opportunities to meet significant unmet medical needs for people with retinal diseases.

Kourous Rezaei, MD, the company’s chief medical officer, says his team’s clinical and drug-development expertise, as well as its strategy of scientific collaboration, enables Ophthotech to break through these formidable technical barriers.

“One point that differentiates us from other companies in this space is that retina specialists are part of our management team,” says Dr. Rezaei. “When retina specialists are directly involved in the process of drug development, they provide an additional perspective on a number of challenges, including the design of the clinical trial. We believe this gives Ophthotech a strategic advantage.”

Dr. Rezaei himself is a practicing retinal specialist at Illinois Retina Associates, and an associate professor in ophthalmology at Rush University Medical Center.

“Ophthotech is currently collaborating with scientists to develop novel gene delivery technology that uses adeno-associated viruses (AAVs),” adds Dr. Rezaei. “The safety profile of AAVs in humans is relatively well-documented compared to other gene therapy technologies currently in development. We are particularly interested in AAV-based delivery systems that can be modulated to target specific retinal cells.”

AAVs are engineered by scientists to deliver therapeutic genes into patients’ cells, including those of the retina. Nearly 20 clinical trials for AAV-based retinal therapies are underway.  LUXTURNA™, which uses an AAV for retinal delivery of the gene RPE65, became the first FDA-approved gene therapy for the eye or an inherited disease in December 2017. However, the AAV technology used in LUXTURNA™ is now more than a decade old.

Dr. Rezaei continues, “The potential to achieve an extended treatment effect and possibly a cure through a single gene therapy administration is particularly appealing to patients who do not have any treatment options available to them, as well as to patients with age-related retinal diseases who may require chronic therapy over years, if not decades.”

Ophthotech is gaining access to emerging, cutting-edge AAV treatments through academic partnerships. It is collaborating with scientists at the University of Florida and University of Pennsylvania to advance a gene knockdown and replacement therapy for patients with autosomal dominant retinitis pigmentosa (adRP) caused by mutations in the gene rhodopsin (RHO). Earlier research for this program was funded by the Foundation Fighting Blindness.  A recent paper in the journal Proceedings of the National Academy of Sciences highlights the success of the Florida-Penn team in canine studies of the RHO gene therapy. The company is planning to launch a clinical trial for RHO gene therapy in 2020.

Ophthotech also recently formed a partnership with the University of Massachusetts Medical School for developing gene therapies that deliver smaller versions of the genes for CEP290 (for LCA) and ABCA4 (for Stargardt disease) ¾ genes that are otherwise too large for existing AAV delivery systems.

“Our expertise is clinical development and its timely execution,” says Dr. Rezaei “Our strategy is to collaborate with universities and companies who have very strong science, and use that science with our clinical expertise to develop novel therapies.  Our team has significant ophthalmic drug development experience and deep relationships with global ophthalmology thought leaders. We have an extensive network of clinical trial sites in ophthalmology, having worked with over 250 sites worldwide.”

Ophthotech also has other clinical trials underway for Zimura®, the company’s product candidate that is designed to target and inhibit complement factor C5. While the complement system plays a critical role in fighting off infection and pathogens, it is implicated in accelerating the progression of certain retinal diseases when not properly modulated. The company’s Zimura clinical trials for people with Stargardt disease, as well as dry and wet forms of AMD are all in Phase II.

The Foundation Fighting Blindness has been a valuable resource for the Zimura clinical trial for Stargardt disease by providing access to natural history data from its ProgStar study, and patient information from www.MyRetinaTracker.org, the Foundation’s global patient registry. If you or someone you know are interested in participating in this clinical trial evaluating Zimura for the potential treatment of Stargardt disease, please call 1-833-STGD1-OP (833-784-3167). Information on all Zimura clinical trials can be found at www.clinicaltrials.gov.

“When we design a clinical trial, we need to know the natural history of the disease, the patients who could potentially be helped the most, and the optimal endpoints for the trial to determine if a treatment is working. These factors may ultimately determine the success of the clinical trial,” says Dr. Rezaei. “With ProgStar, the largest natural history study ever done in patients with Stargardt disease, we were able to use the study results to help design our clinical trial. If the Foundation had not been there, it would have been more difficult, and may not have even been feasible, to design our trial.”

 

https://www.lvcenter4sight.com/ophthotech-is-advancing-an-impressive-portfolio-of-cutting-edge-therapies-for-retinal-diseases/